Research shows that death cap, the deadliest mushroom, is continually producing new toxins

A recent report illustrates the deadliest nature of death cap mushrooms. Amanita phalloides has been connected to poisonings once more, this time in beef Wellingtons given at a family lunch in Leongatha, Australia, resulting in three deaths. Such events eventually revive popular concern of this lethal fungus, and mushrooms in general. The fact that death caps appear so innocent simply adds to their sinister allure. With their pale yellow crown and white gills, they can be mistaken for a variety of edible fungus, which may explain why they account for nearly all mushroom-related fatalities. Just half of one will kill you.

ALSO READ: The crust of Venus is surprisingly thin. Could this be the reason for its high geological activity?

Despite its attention-grabbing nature, the death cap is just one of many amazing mushrooms. They are more closely linked to animals than plants and make up a whole kingdom of life, with an estimated 5 million species. Although just 5% have been properly described, those we know about include some extremely bizarre. Cordyceps mushrooms (Ophiocordyceps unilateralis), for example, emerge from infected and zombified ants’ bodies, stinkhorns (Phallus impudicus) secrete a foul-smelling slime that mimics rotting flesh, and dead man’s fingers (Xylaria polymorpha) emerge from forest floors as eerie black appendages.

In comparison, death caps look unremarkable. Nonetheless, their toxicity makes them the focus of ongoing scientific inquiry. And the findings are fascinating: recent research show a quickly evolving species that produces novel poisons, thrives in new settings, and spreads over the world. These discoveries are not just changing our knowledge of the death cap, but of the whole fungal world. Furthermore, they have the ability to transform public attitudes of fungus from fear to educated enjoyment. Read full article here.

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The crust of Venus is surprisingly thin. Could this be the reason for its high geological activity?

According to a recent study, Venus, which is sometimes written off as a geologically dead planet, is significantly more active under its scorching surface than previously believed.

The geological churn of plate tectonics, which frequently recycles and shapes Venus‘ surface, is absent from Earth. For many years, scientists believed that Venus’ crust would progressively thicken without this mechanism as fresh rock piled on top of it. But underneath the surface of this globe, another type of planetary engine may be at work, one that, once it hits a certain threshold, causes the crust to melt or break off, preventing it from growing eternally.

“This breaking off or melting can put water and elements back into the planet’s interior and help drive volcanic activity,” said Justin Filiberto, a co-author of the paper and the deputy chief of NASA’s Astromaterials Research and Exploration Science Division in Houston. “It resets the playing field for how the geology, crust and atmosphere on Venus work together.”

Julia Semprich, a planetary scientist at The Open University in the United Kingdom, led the latest study, which utilised computer models to explore how various rock types in Venus’ crust might respond to the intense heat and pressure of the planet.

ALSO READ: A recent study shows scientists working to find out why the universe exists

According to the results, the planet’s crust goes through a process known as metamorphism, whereby the bottom layers peel off and sink deeper as the crust expands because they are heavier than the mantle below. According to the study, the planet’s crust is probably no thicker than 40 miles (65 km) at its maximum, and it may be considerably thinner in many locations.

“That is surprisingly thin, given conditions on the planet,” Filiberto mentioned in the statement. Despite the absence of plate tectonics, the researchers hypothesise that this process may account for Venus’s continued geological activity.

Recent analyses of archival data from NASA’s Magellan mission have also challenged long-held assumptions about Venus’s geological dormancy, revealing compelling evidence of volcanic activity as recent as the early 1990s.

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A recent study shows scientists working to find out why the universe exists

One of the most important topics in science is being investigated inside a lab tucked away above the fog of South Dakota’s forests: why the universe exists?

Another group of Japanese scientists, who are many years ahead of them, are competing with them for the solution.

The origins of planets, stars, and galaxies are beyond the current understanding of astronomy. In an effort to uncover answers, both teams are constructing detectors that investigate a subatomic particle known as a neutrino.

The appropriately called Deep Underground Neutrino Experiment (Dune) is where US scientists are trying to find the solution.

The researchers enter three enormous subterranean caves 1,500 meters below the surface. It’s so big that, in comparison, construction workers and their bulldozers are like little plastic toys.

The enormous caverns are referred to as “cathedrals to science” by Dr. Jaret Heise, the science director for Dune.

ALSO READ: Researchers in Quantum Physics found evidence of “Negative Time”

For almost a decade, Dr. Heise has been involved in the caves’ construction. They isolate Dune from the radiation and noise of the outside world. Dune is now prepared for the following phase.

“We are poised to build the detector that will change our understanding of the universe with instruments that will be deployed by a collaboration of 1,500 scientists who are eager to answer the question of why we exist,” he continues.

Two types of particles were generated at the beginning of the universe: matter, which is the building block of stars, planets, and everything else in our environment, and antimatter, which is the exact opposite of matter and is also present in equal proportions.

In theory, the two ought to have neutralized one another, leaving just a powerful energy spike. Nevertheless, here we are, as matter.

Scientists think that researching the neutrino and its antimatter opposite, the anti-neutrino, will help them understand why matter prevailed and why we are here.

They will be sending beams of both types of particles to the detectors in South Dakota, which are 800 miles apart, from deep below in Illinois.

This is due to the fact that neutrinos and antineutrinos undergo minute changes along their journey.

If such alterations are different for neutrinos and antineutrinos, that is what the scientists want to know. The solution to the question of why matter and antimatter do not cancel each other out may be revealed if they are.

Several years ahead of the American effort, the Japanese-led team will be prepared to activate its neutrino beam in less than two years. Hyper K is a multinational corporation, much like Dune. According to Dr. Mark Scott of Imperial College in London, his team is poised to produce one of the most significant findings about the universe’s origins.

“We switch on earlier, and we have a larger detector, so we should have more sensitivity sooner than Dune,” he explains.

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Scientists will learn more from two trials running simultaneously than from just one, but “I would like to get there first!” he says.

However, the Japanese-led team may not gain a complete picture of what is actually happening if they arrive first, according to Dr. Linda Cremonesi of Queen Mary University of London, who works on the US project.

“There is an element of a race, but Hyper-K does not yet have all of the ingredients that they need to understand if neutrinos and antineutrinos behave differently.”

Although the race has begun, the first outcomes are not anticipated for some years. For the time being, the exact event that created humankind at the beginning of time is still unknown.

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Researchers in Quantum Physics found evidence of “Negative Time”

Researchers at the University of Toronto claim to have shown through groundbreaking quantum experiments that “negative time” is more than just a theoretical concept; it exists in a concrete, physical sense and merits further investigation.

It has long been known by scientists that light may appear to leave a substance before entering it; this phenomenon is thought to be an illusion brought on by the way matter distorts wavelengths. A recent report.

The results have drawn skepticism and international attention, but they have not yet been published in a peer-reviewed publication.

ALSO READ: Earth bacteria ‘rapidly colonized’ a sample from Japan’s precious asteroid Ryugu

The researchers demonstrate that these puzzling findings do not point to a fundamental change in how we think about time, but rather to a strange feature of quantum physics.

“This is difficult material, even for us to discuss with other physicists. Aephraim Steinberg, a professor of experimental quantum physics at the University of Toronto, stated, “We are frequently misunderstood.”

Steinberg supports the usage of the phrase “negative time” despite the fact that it may seem like a notion taken from science fiction in the hopes of igniting more in-depth conversations about the enigmas of quantum physics.

The idea of “negative time” has generated interest as well as skepticism, especially from well-known scientists.

In one YouTube video that was watched by more than 250,000 people, German theoretical physicist Sabine Hossenfelder criticized the work, saying, “The negative time in this experiment has nothing to do with time—it’s just a way to describe how photons travel through a medium and how their phases shift.”

Angulo and Steinberg resisted, claiming that their study fills important knowledge gaps about why light doesn’t always move at the same pace.

Steinberg noted that no credible scientist had questioned the experimental findings, even acknowledging the controversy surrounding the aggressive headline of their work.

He said that although real-world uses are still elusive, the results provide new opportunities to study quantum phenomena.

Earth bacteria ‘rapidly colonized’ a sample from Japan’s precious asteroid Ryugu

Researchers have found that after being transported to Earth, a sample of the asteroid Ryugu was infested with life forms from Earth. The study demonstrates the efficacy of terrestrial microorganisms in colonizing extraterrestrial materials.

The samples under investigation were from the spacecraft Hayabusa2, operated by the Japan Aerospace Exploration Agency (JAXA), which launched in December 2014 and made contact with Ryugu in June 2018. After monitoring the asteroid for a year, Haybusa2 dove to the surface and collected a sample. The asteroid is about 3,000 feet (900 meters) in diameter.

On December 6, 2020, the Ryugu sample was sent back to Earth, but Haybusa2 went on to investigate further asteroids. The sample was divided up and sent to several scientific teams, including the one responsible for this remarkable finding.

“We found microorganisms in a sample returned from an asteroid.”.

ALSO READ: Astronomers capture a photograph of Earth’s vanishing mini-moon: Will it reappear as a “second moon?”

After first appearing on the rock, they gradually dispersed until eventually going extinct, Imperial College London team leader Matthew Genge told Space.com. “The shift in the quantity of microorganisms verified that these were live bacteria. However, it also suggested that they were terrestrial in origin and had only recently colonized the specimen before our studies.

The scientists identified the findings as filamentous microorganisms since it appeared as rods and threads of organic materials. Although the team is unsure of the precise sort of microbes they were, Genge has a fair sense of what they may be.

The researcher stated, “It is impossible to identify their exact type without studying their DNA.” “However, they were most likely bacteria such as Bacillus since these are very common filamentous microorganisms, particularly in soil and rocks.”

It demonstrates that microbes may easily metabolize and survive on materials from other planets. Homegrown organic matter is plentiful on Earth, but extra-martian organic matter may sustain an ecosystem on worlds like Mars.
We can never fully rule out terrestrial contamination since terrestrial microorganisms are the finest colonizers on Earth,” the researcher added. “As long as you know where it comes from, contamination is usually not an issue. The issue arises when scientists try to assert that a specimen’s “pristine” state proves that its traits are alien.

The research was published in the journal Meteoritics & Planetary Science.

Read the full article here.

Astronomers capture a photograph of Earth’s vanishing mini-moon: Will it reappear as a “second moon?”

A stunning photograph from the Two-Meter Twin Telescope in Spain shows a transient mini-moon that was entangled by Earth’s gravity for over two months before returning to the solar system. The gravitational pull of our planet attracted the near-Earth asteroid (NEO) 2024 PT5. Scientists examining this “second moon,” such as Carlos de la Fuente Marcos of the Universidad Complutense de Madrid, knew from the beginning of its occupation that it would be a “temporary capture” that would only last a few weeks.

Officially, the mini-moon is called asteroid 2024 PT5. Initially connecting with Earth on September 29, 2024, the mini-moon departed our planet’s orbit at 10:43 A.M. EST (1543 GMT) on Monday, November 25, failing to stay long enough to observe Thanksgiving on Thursday, November 28.

Marcos and his associates have been examining it using the Two-meter Twin Telescope (TTT), run by the Santa Cruz de Tenerife, Spain-based Instituto de Astrofísica de Canarias (IAC). As a result, the team was able to learn several things about the asteroid, such as the possibility that it is a fragment of the moon that was pierced by an asteroid impact. The departure of 2024 PT5 and the end of its tenure as Earth’s second moon did not cause the astronomers to cry too much, but they nevertheless managed to image it as it passed.

“The ‘see-you-soon’ picture of 2024 PT5 was acquired on Monday by Dr. Miquel Serra-Ricart, a member of our collaboration,” Marcos told Space.com via email. “The observation came from the TTT.”

ALSO READ: Chinese researchers demonstrate the efficacy of early insulin treatment for type 2 diabetes

But don’t let this leave make you unhappy. The asteroid, which is 37 feet wide (11.2 meters), or six stacked Arnold Schwarzeneggers, will return like Arnie from “The Terminator.” Will 2024 PT5 get another opportunity to orbit the Earth as a second moon?

This asteroid is often found in the Arjuna asteroid belt, a secondary asteroid belt made up of rocks that orbit the sun in orbits that are very similar to Earth’s, Marcos told Space.com. The average distance between these Arjuna asteroids and the central star of the solar system is around 93 million miles (150 million km).

The next few approaches of 2024 PT5 can be analyzed using the NASA JPL small body lookup database to at least tentatively determine which will fit the requirements for its capture.

The database, which includes information on the orbits of more than 3.3 million known asteroids and comets, indicates that 2024 PT5 will next approach Earth on January 9, 2025. At this point, the asteroid will be traveling at around 2,300 mph (3,700 kph) and will approach Earth within 1.1 million miles (1.8 million km).

This suggests that the asteroid may be moving a bit too quickly to be gravitationally captured by Earth during this encounter, which will also see it approach the moon closely a few days later.
Astronomers will then have to wait until 2024 PT5 returns, since its next near approach is scheduled for November 8, 2055.

At that point, the asteroid will approach Earth more slowly—just 1,498 miles per hour—but it will only go within 3.3 million miles. This implies that the 2055 approach could be just a bit too broad for PT5 to be captured by Earth as a mini-moon in 2024.

Chinese researchers demonstrate the efficacy of early insulin treatment for type 2 diabetes

Chinese researchers have shown that early insulin therapy can lower the incidence of stroke and heart failure-related hospitalization for newly diagnosed type 2 diabetes (T2D) patients as compared to those who have not received the medication; a report published in CGTN.

Type 2 diabetes mellitus is a group of dysfunctions that are typified by elevated blood glucose levels and are caused by a combination of insulin action resistance, insufficient insulin production, and excessive or incorrect glucagon secretion. Take a look at the picture below.

Researchers from the University of Science and Technology of China, Southern Medical University, Peking University, and Professor Weng Jianping of Anhui Medical University collaborated to conduct a 24-year observational study on the care of 5,424 T2D patients nationwide.

Read: Starfish that consume coral may benefit from global warming

They found that newly diagnosed T2D patients who underwent the therapy experienced a 31 percent reduced risk of stroke and a 28 percent lower risk of hospitalization due to heart failure.

This study also shows that early insulin treatment can help newly diagnosed T2D patients’ biomarkers for low-grade inflammation and endothelial function—both of which are established indications of cardiovascular risk.

This offers strong support for starting early insulin therapy as the first course of treatment for those who have just received a diagnosis.

Source(s): Xinhua News Agency

Starfish that consume coral may benefit from global warming

A recently published report highlights that coral bleaching is being made worse by global warming. But, according to Australian scientists, it might also promote the growth of crown-of-thorns starfish, a type of predatory starfish extremely resilient to marine heat waves and feeding on coral reefs.

The crown-of-thorns starfish (Acanthaster) is frequently referred to as the worst enemy of corals. These starfish are herbivores when they are young. But as they grow older, they become carnivores that eat coral reefs. According to marine biologists from Australia’s University of Sydney, juveniles “have potential for long-term persistence as herbivores as they wait for live coral to recover before becoming coral predators.” They used heat stress scenarios intended to simulate the impact of marine heatwaves, replicating the circumstances that lead to coral bleaching and mortality, to assess the resilience of young crown-of-thorns starfish.

Also read: Global Warming threat by livestock and its control

Two aluminum blocks set parallel to each other and with hot and cold water inlets at each end were used to create these circumstances for the starfish trials. The temperatures of 28°C, 29°C, and 30°C were tested in three different heat wave scenarios. The reference temperature was 27°C, the maximum mean summer sea surface temperature to which Acanthaster sea stars are exposed in the southern Great Barrier Reef. The optimum temperature for coral bleaching in the same area is 28.3°C. The study found that coral was not as resilient to hot conditions as starfish.

According to study findings reported in the journal Global Change Biology, young crown-of-thorns starfish survived 20 days of high temperatures. “We found juvenile crown-of-thorns starfish can tolerate almost three times the heat intensity that causes coral bleaching, using a model that measures temperature over time.” This is an important finding that has implications for understanding the impacts of climate change on marine ecosystems.

Global Warming threat by livestock and its control

The sun provides the energy necessary for life on Earth. The environment and living things are being impacted by global warming. Roughly 50% of the light that enters Earth’s atmosphere is absorbed at the surface and reflected upward as infrared heat after passing through clouds and air. The surface is subsequently heated to an average temperature of 59 degrees Fahrenheit (15 degrees Celsius), which is sufficient for life after around 90% of this heat is absorbed by the greenhouse gases.

Is the sun to blame?

How do we know that changes in the sun aren’t to blame for current global warming trends?

Several satellite devices have been directly measuring the sun’s energy output since 1978. During this time, there appears to have been a very modest decrease in solar irradiance, a measurement of the amount of energy the sun emits, according to satellite data. Thus, the warming trend that has been shown over the past 30 years does not seem to be caused by the sun. Sunspot records and other so-called “proxy indicators,” including the amount of carbon in tree rings, have been used to estimate solar irradiance over longer periods. According to the most current assessments of these proxies, variations in solar irradiance are not likely to be responsible for more than 10% of the warming observed in the 20th century.

Global warming and livestock

Methane, which makes up 16% of all greenhouse gas emissions worldwide resulting from human activity, is the second most significant greenhouse gas after carbon dioxide. Methane has a 21-fold greater potential for global warming than carbon dioxide. After rice fields, ruminant methane production has been identified as the single biggest source of anthropogenic CH4. Methane is naturally released by livestock throughout their digestive processes. Billions of bacteria, methanogens, protozoa, and fungi live in the rumen, where they break down the grain to create methane, carbon dioxide, ammonia, and volatile fatty acids (VFAs). Animals use volatile fats (VFAs) as a source of energy, whereas gases are expelled by the mouth and the rectum. Cattle can produce 250–500 liter of methane per day per animal and generally lose 2–15% of their ingested energy as eructated methane. Approximately 100 million tonnes of methane are produced annually by cattle, and when these emissions are multiplied by the number of animals worldwide, the total emissions from cattle represent 15% of all methane emissions. Therefore, cutting back on methane emissions from cattle, especially from cows, is an excellent strategy to reduce methane emissions globally. However, there are both financial and environmental advantages to reducing ruminant methane leaks. reduced methane levels translate into reduced atmospheric concentrations of greenhouse gases. Additionally, less methane equals better animal production efficiency and higher farmer revenue. The content of the animal feed can be changed to regulate a higher level of methane output. Changing the feed composition, either to reduce the protein percentage which is converted into methane or to enhance the meat and milk yield has been considered the most efficient methane reduction strategy. Enhancement in the overall quality of animal feed may prove helpful in maintaining meat and dairy production at the same level with fewer animals and so less total methane emission.

Natural sources, such as wetlands, as well as man-made ones, including rice fields, biomass, ruminants, etc., all emit methane into the atmosphere. To reduce greenhouse gas emissions globally and improve animal performance through increased feed conversion efficiency, it is often necessary to mitigate methane (CH4) losses from ruminants. Monogastric animals—such as pigs, chickens, rabbits, etc.—contribute extremely little methane to the atmosphere as compared to ruminant emissions. The fact that ruminant animals may create 250–500 L of methane per day makes it crucial to research and attempt to reduce the emissions from cattle.

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Energy losses and methane production in the digestive tract of ruminants:

The synthesis of the methane in ruminants reflects energy loss and it is due to the reduction of the carbon dioxide by methanogenic bacteria. After the feed is digested in the rumen, some of the energy is lost in the form of heat or methane, giving a production of methane utilizing between 11 and 13% of the digestible energy

Dietary manipulation

Roughages (Forage type and quality):

The composition and quality of forage along with the level of intake significantly influences the rumen fermentation. Ruminants fed low-quality roughages could release a large amount of methane. Feeding crop residues to ruminants is a common practice in many Asian countries due to which methane emission from ruminants especially cattle is significant. 15% reduction in methane production by increasing the digestibility of forages and 7% by increasing feed intake. Grinding and pelleting operations of roughages decrease methane production by improving the passage rate and reducing the time of feed. The shifting of animals from low to high digestible pasture significantly reduced methane production per gram of live weight gain. The use of forages meant to improve animal performance can reduce methane emissions per unit of feed intake. Importantly, pasture improvement can be a good choice if fewer animals are used

Concentrates:

The methane production differs depending on the different types of carbohydrates that are fermented. The fermentation of cell wall fiber will lead to the production of a higher proportion of acetic acid in the rumen. In contrast, starch fermentation gives a higher proportion of propionic acid due to the lowered pH in the rumen which causes changes in the ruminal micro-flora by an increase of amylolytic microbes and a decrease of cellulolytic microbes.

The end products of the fermentation the Volatile Fatty Acids (VFA) are mainly acetate, propionate, and butyrate, we can also find valerate, isovalerate, isobutyrate, and caproate but in very low proportions.  They are also the main source of energy for the ruminants, and this energy is used by the lactating cow to produce milk and body fat, but not all VFAs have the same degree of efficiency. Propionic acid fermentation is more efficient in the use of energy than acetic and butyric acids which have a large loss of methane. The type of VFA produced by the animal influences the release of methane and hydrogen, increasing the release of methane when the relation of ruminal VFA [acetic acid+butyric acid]/propionic acid increases there is a negative correlation between the proportion of concentrate and methanogenesis. A significant reduction in methane production was reported in young bulls fed with a diet containing more than 40% starch. A diet comprising 45% starch decreased methane production by 56% compared to diets containing 30% starch without affecting animal health.

The inclusion of starch in the diet has a significant impact on changing ruminal pH and microbial populations.

As concentrate contains more soluble substances, the addition of concentrate to animal diet changes the composition of partial short-chain fatty acids (SCFA) from higher to lower acetate production and more propionate. Similarly, milk quality is negatively affected if concentrates exceed 50% which limits the use of concentrates to lower methane emissions in the dairy sector.

Cereal grains with a high proportion of starchy endosperms like wheat, barley, or oats have an easier and faster fermentation giving less methane than those that have a lower proportion like maize, and sorghum.

Lipids:

Lipids and lipid-rich feeds are among the most efficient and emerging options for methane mitigation. Lipid inclusion in the diet reduces methane emissions by decreasing fermentation. Saturated medium-chain fatty acids, C10-C14, also lead to methane reduction. At ruminaL temperature, an increasing chain length of medium chain fatty acids seems to reduce their efficiency in inhibiting methanogens and methane formation due to lower solubility reviewed the practical application of lipids to reduce methanogenesis. Oil supplementation to diet decreased methane emission by up to 80% in vitro and about 25% in vivo. The toxic effects of certain oils on rumen protozoa contributed to reduced methane production. The addition of canola oil at 0%, 3.5%, or 7% to the diets of sheep reduced the number of rumen protozoa by 88–97%. The detrimental impact of unsaturated fatty acids has also been reported. Coconut oil is a more effective inhibitor followed by rapeseed, sunflower seed, and linseed oil.

The inclusion of sunflower oil in the diet of cattle resulted in a 22% decrease in methane emission. However, fats and oils may pose numerous negative impacts to the animals. Dietary oil supplementation caused lower fiber digestibility. High cost and the negative impact on milk fat concentration are some of the limitations of oil supplementation.

Miscellaneous activities to reduce methane emission:

Increased milk yield:

The milk yield also influences the production of methane, when milk yield increases, the methane per kilo of milk decreases. This is logical and can be explained by the fact that the energy needed for maintenance is considered approximately the same for the animal irrespective of production level. The methane production that originates from maintenance needs is therefore also estimated to be the same for an individual animal of a specific weight. When the milk yield increases, the DMI also increases but not in the same proportion. With the increased milk yield, there is more milk to carry the “burden” of maintenance needs and methane per kg milk will decrease. Thus, with increased milk yield the methane produced in absolute terms will increase somewhat but the methane per kg of milk will decrease.

Using of feed additives:

Some additives like ionophores and particularly monensin have been studied. Monensin is a broad-spectrum antibiotic obtained from actinomycete Streptomyces cinnamonensis used in some countries. It is not allowed in the European Union but it is used in the United States. Its main action is to change the fermentation from acetate to propionate which leads to the decrease of methane production. However, the widespread use of antibiotics can lead to future problems with bacteria that are resistant to antibiotics and the environmental and economic advantages of using antibiotics to decrease methane production must be weighed against the negative health effects of increased resistance.

Feed intake level:

The level of intake can also affect methane production when an animal increases its intake, the percentage of gross energy lost in the form of methane decreases

The role of human activity

In its Fourth Assessment Report, the Intergovernmental Panel on Climate Change, a group of 1,300 independent scientific experts from countries all over the world under the auspices of the United Nations, concluded there’s a more than 90 percent probability that human activities over the past 250 years have warmed our planet.

The industrial activities that our modern civilization depends upon have raised atmospheric carbon dioxide levels from 280 parts per million to 400 parts per million in the last 150 years. The panel also concluded there’s a better than 90 percent probability that human-produced greenhouse gases such as carbon dioxide, methane, and nitrous oxide have caused much of the observed increase in Earth’s temperatures over the past 50 years.

They said the rate of increase in global warming due to these gases is very likely to be unprecedented within the past 10,000 years or more.

Authors: Naila Riaz, Maryam Saleem, and Hafiz Hasnain Ayoub

The Islamia university of Bahawalpur, Pakistan.

Ebola virus disease: A real threat

Formerly known as Ebola hemorrhagic fever, the Ebola virus illness is considered to be “one of the world’s most virulent diseases.” According to reports, the EVD pandemic mostly affected a rural town in Central and West Africa, close to a tropical rainforest. Fatality rates from the outbreak ranged from 50 to 90%.

Introduction

Group: Group V(-)ssRNA

Order: Mononegavirate

Family: Filoviridae

Genus: Ebolavirus

Species: Zaire ebolavirus

There are five known viruses in the genus Ebolavirus, and the Ebola virus (EBOV, formerly known as Zaire ebolavirus) is one of them. 1976 saw the emergence of the first Ebola virus illness (EVD). in two epidemics that happened at the same time, one in Yambukku, Democratic Republic of the Congo, and one in Nzara, Sudan. Five species—Zaire, Bundibugyo, Sudan, Reston, and Tai Forest—have been identified. Ebolaviruses from Sudan, Zaire, Bundibugyo, and Zaire have all been linked to significant outbreaks in Africa. The Zaire variety of viruses responsible for the 2014 West African outbreaks is known as VHF.
The diseases that fall within the families Arenaviridae, Filoviridae, Bunyaviridae, Flaviviridae, and Rhabdoviridae range in severity from less serious conditions like Lassa fever, Rift Valley fever, yellow fever, and Dengue fever to more serious conditions that can be fatal, such Marburg hemorrhagic fever and Ebola viral infections. Extreme systemic signs, such as substantial vascular injury leading to multiple organ failure and hemorrhaging, are frequently indicative of severe types. Fruit bats are the natural reservoir, and bodily fluids are the main way that people and animals may contract the disease from one another.

The single-stranded RNA that makes up the Ebola genome has a length of about 19000 nucleotides. It encodes seven structural proteins, including the polymerase cofactor (VP35) and nucleoprotein (NP). (VP40), GP, RNA-dependent RNA polymerase, transcription activator (VP30), and (VP24).

Read: Global Warming threat by livestock and its control

Treatment

Ebola, however, has no known treatment. Despite efforts by experts, there is currently no treatment for Ebola. A serum under investigation that kills contaminated cells is part of the treatment. Promptly diagnosed and treated Ebola symptoms and consequences. Early use of the following simple therapies can greatly increase the likelihood of survival:

  1. Providing intravenous fluids (IV) and balancing electrolytes (body salts).
  2. Maintaining oxygen status and blood pressure

There is currently no commercially available vaccine, cure, or therapy for Ebolavirus infection. Carette et al. (2011) suggested that blocking the NPC1 cholesterol transporter might be a way to develop possible anti-filovirus medications. This has been shown to prevent EBOV infection in mice, but it would also obstruct the cholesterol transport system, therefore a cure has not yet been discovered for this type of therapy. Ebola patients should be treated in facilities specifically designed for that purpose and by medical professionals who have received specialised training in treating them. Ebola patients need a comprehensive approach to treatment. Thus, the following medication aids in the management of pain:

  1. Antipyretic agents (eg, acetaminophen, paracetamol) to decrease fever associated with Ebola virus disease. A dose reduction of these agents may be needed for patients with progressive hepatic dysfunction. Nonsteroidal anti-inflammatory agents are generally avoided to help minimize the risk of renal failure, which can contribute to fatal disease.
  2. Analgesic agents to manage pain (eg, abdominal, joint, muscle).
  3. Antiemetic medications to control nausea and vomiting.

Anti-motility agents (eg, loperamide) to control diarrhea, and decrease fluid and electrolyte losses.

Infection

 The virus enters the body via cuts or through exposed mucous membranes like the eyes. Symptoms usually occur 2-21 days later. The infectious period occurs with the symptoms, are fever, muscle pain, headache, sore throat, nausea, diarrhea, rash, and kidney & liver problems. The final stages involve external bleeding such as from the gums & in the stools. The virus can also remain in semen for 7 weeks after recovery from infection, it can spread via breast milk & through contact with an infected deceased individual.

Ebola is a rare but deadly virus that causes bleeding inside and outside the body.

As the virus spreads through the body, it damages the immune system and organs. Ultimately, it causes levels of blood-clotting cells to drop. This leads to severe, uncontrollable bleeding. The disease, also known as Ebola hemorrhagic fever or Ebola virus, kills up to 90% of people who are infected.

Virus transmission

It is not entirely known how Ebola spreads in humans, but contact with body fluids of infected humans or animals is primarily responsible for the virus outbreak. Fruit bats are the natural reservoirs of the virus.

Ebola virus transmission from fruit bats to humans. The virus is transmitted by contact with contaminated body fluids.

Avoid Ebola Virus

There’s no vaccine to prevent or avoid the Ebola virus. To avoid the Ebola virus we have to take care of prevention. The things are:

  1. Avoid direct contact with blood, saliva, vomit, urine, and other bodily fluids of people with EVD or unknown illness.
  2. Avoid close contact with wild animals and avoid handling wild meat.
  3. Healthcare workers can prevent infection by wearing masks, gloves, and goggles whenever they come into contact with people who may have Ebola.

Conclusion

Pharmacists and microbiologists can play a large role in the management of the Ebola virus by educating and reassuring the public, particularly those traveling to endemic areas. As healthcare professionals, pharmacists are suitably placed to advise the general public on what measures can be taken to minimize the risk of infection, what symptoms to watch out for, and how to seek medical advice if contact is made with the Ebola virus.

Author: Terisa